RapamycinFungusV1, Main, Exploration, bibRecord, 000182

Vitamin C and B3 as new biomaterials to alter intestinal stem cells.

Identifieur interne : 000182 ( Main/Exploration ); précédent : 000181; suivant : 000183

Vitamin C and B3 as new biomaterials to alter intestinal stem cells.

Auteurs : Yijun Qi [États-Unis] ; Jo Lohman [États-Unis] ; Kaitlin M. Bratlie [États-Unis] ; Nathan Peroutka-Bigus [États-Unis] ; Bryan Bellaire [États-Unis] ; Michael Wannemuehler [États-Unis] ; Kyoung-Jin Yoon [États-Unis] ; Terrence A. Barrett [États-Unis] ; Qun Wang [États-Unis]

Source :

Journal of biomedical materials research. Part A [ 1552-4965 ] ; 2019.

RBID : pubmed:31071241

Descripteurs français

KwdFr :
- Acide ascorbique (pharmacologie), Animaux (MeSH), Cellules souches (cytologie), Cellules souches (métabolisme), Mucine-2 (biosynthèse), Muqueuse intestinale (cytologie), Muqueuse intestinale (métabolisme), Nicotinamide (pharmacologie), Régulation positive (effets des médicaments et des substances chimiques), Souris (MeSH).
MESH :
- biosynthèse : Mucine-2.
- cytologie : Cellules souches, Muqueuse intestinale.
- effets des médicaments et des substances chimiques : Régulation positive.
- métabolisme : Cellules souches, Muqueuse intestinale.
- pharmacologie : Acide ascorbique, Nicotinamide.
- Animaux, Souris.

English descriptors

KwdEn :
- Animals (MeSH), Ascorbic Acid (pharmacology), Intestinal Mucosa (cytology), Intestinal Mucosa (metabolism), Mice (MeSH), Mucin-2 (biosynthesis), Niacinamide (pharmacology), Stem Cells (cytology), Stem Cells (metabolism), Up-Regulation (drug effects).
MESH :
- chemical , biosynthesis : Mucin-2.
- chemical , pharmacology : Ascorbic Acid, Niacinamide.
- cytology : Intestinal Mucosa, Stem Cells.
- drug effects : Up-Regulation.
- metabolism : Intestinal Mucosa, Stem Cells.
- Animals, Mice.

Abstract

Vitamin C (ascorbic acid) and vitamin B₃ (niacin) have been extensively studied since the 20th century. In the area of stem cell biology, vitamin C has shown its direct impact toward homeostasis and epigenetic changes (D'Aniello et al., Stem Cells International, 2017, 1-16). Vitamin B₃ aids in maintaining healthy intestinal homeostasis and reducing gut inflammation by participating in the rapamycin signaling pathway (Kumar et al., The American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013). In this study, vitamin C and vitamin B₃ (600 and 1,200 μg/mL) have been explored as potential new biomaterials to study their effects on four types of intestinal stem cells which are isolated from mice bearing different microbiota. We observed that C3H ASF and 129 ASF IL-10 are more sensitive towardB7 600 μg/mL vitamin B₃ and 1,200 μg/mL vitamin C. The lowest growth rate and viability for all types of organoids was with 1,200 μg/mL vitamin C. From quantitative polymerase chain reaction analysis (qPCR analysis), MUC2 was upregulated for 129 ASF and C3H Conv when exposed to 600 μg/mL and 1,200 μg/mL vitamin C. It suggests that large amounts of glycoprotein may be produced after adding high concentrations of vitamin C. Since inflammatory bowel disease has low level of MUC2, this finding may be helpful in restoring mucosal health by upregulating the MUC2 gene while altering patient's microbiota (Sibila et al., Annals of the American Thoracic Society, 2016). These results are expected to have a positive translational impact because this bottom-up strategy would be instrumental in developing Vitamin C and B3 based orally available therapeutic strategies and formula for advancing the fields of gastrointestinal regenerative medicine.

DOI: 10.1002/jbm.a.36715
PubMed: 31071241
PubMed Central: PMC6626554

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000276
to stream Main, to step Curation: 000276

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Ascorbic Acid (pharmacology)</term>
<term>Intestinal Mucosa (cytology)</term>
<term>Intestinal Mucosa (metabolism)</term>
<term>Mice (MeSH)</term>
<term>Mucin-2 (biosynthesis)</term>
<term>Niacinamide (pharmacology)</term>
<term>Stem Cells (cytology)</term>
<term>Stem Cells (metabolism)</term>
<term>Up-Regulation (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide ascorbique (pharmacologie)</term>
<term>Animaux (MeSH)</term>
<term>Cellules souches (cytologie)</term>
<term>Cellules souches (métabolisme)</term>
<term>Mucine-2 (biosynthèse)</term>
<term>Muqueuse intestinale (cytologie)</term>
<term>Muqueuse intestinale (métabolisme)</term>
<term>Nicotinamide (pharmacologie)</term>
<term>Régulation positive (effets des médicaments et des substances chimiques)</term>
<term>Souris (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Mucin-2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ascorbic Acid</term>
<term>Niacinamide</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Mucine-2</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches</term>
<term>Muqueuse intestinale</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Intestinal Mucosa</term>
<term>Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Up-Regulation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Régulation positive</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intestinal Mucosa</term>
<term>Stem Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches</term>
<term>Muqueuse intestinale</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide ascorbique</term>
<term>Nicotinamide</term>
</keywords>
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<term>Mice</term>
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<front><div type="abstract" xml:lang="en">Vitamin C (ascorbic acid) and vitamin B<sub>3</sub>
 (niacin) have been extensively studied since the 20th century. In the area of stem cell biology, vitamin C has shown its direct impact toward homeostasis and epigenetic changes (D'Aniello et al., Stem Cells International, 2017, 1-16). Vitamin B<sub>3</sub>
 aids in maintaining healthy intestinal homeostasis and reducing gut inflammation by participating in the rapamycin signaling pathway (Kumar et al., The American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013). In this study, vitamin C and vitamin B<sub>3</sub>
 (600 and 1,200 μg/mL) have been explored as potential new biomaterials to study their effects on four types of intestinal stem cells which are isolated from mice bearing different microbiota. We observed that C3H ASF and 129 ASF IL-10 are more sensitive towardB7 600 μg/mL vitamin B<sub>3</sub>
 and 1,200 μg/mL vitamin C. The lowest growth rate and viability for all types of organoids was with 1,200 μg/mL vitamin C. From quantitative polymerase chain reaction analysis (qPCR analysis), MUC2 was upregulated for 129 ASF and C3H Conv when exposed to 600 μg/mL and 1,200 μg/mL vitamin C. It suggests that large amounts of glycoprotein may be produced after adding high concentrations of vitamin C. Since inflammatory bowel disease has low level of MUC2, this finding may be helpful in restoring mucosal health by upregulating the MUC2 gene while altering patient's microbiota (Sibila et al., Annals of the American Thoracic Society, 2016). These results are expected to have a positive translational impact because this bottom-up strategy would be instrumental in developing Vitamin C and B3 based orally available therapeutic strategies and formula for advancing the fields of gastrointestinal regenerative medicine.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>11</Day>
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<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>01</Day>
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<JournalIssue CitedMedium="Internet"><Volume>107</Volume>
<Issue>9</Issue>
<PubDate><Year>2019</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Journal of biomedical materials research. Part A</Title>
<ISOAbbreviation>J Biomed Mater Res A</ISOAbbreviation>
</Journal>
<ArticleTitle>Vitamin C and B<sub>3</sub>
 as new biomaterials to alter intestinal stem cells.</ArticleTitle>
<Pagination><MedlinePgn>1886-1897</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/jbm.a.36715</ELocationID>
<Abstract><AbstractText>Vitamin C (ascorbic acid) and vitamin B<sub>3</sub>
 (niacin) have been extensively studied since the 20th century. In the area of stem cell biology, vitamin C has shown its direct impact toward homeostasis and epigenetic changes (D'Aniello et al., Stem Cells International, 2017, 1-16). Vitamin B<sub>3</sub>
 aids in maintaining healthy intestinal homeostasis and reducing gut inflammation by participating in the rapamycin signaling pathway (Kumar et al., The American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013). In this study, vitamin C and vitamin B<sub>3</sub>
 (600 and 1,200 μg/mL) have been explored as potential new biomaterials to study their effects on four types of intestinal stem cells which are isolated from mice bearing different microbiota. We observed that C3H ASF and 129 ASF IL-10 are more sensitive towardB7 600 μg/mL vitamin B<sub>3</sub>
 and 1,200 μg/mL vitamin C. The lowest growth rate and viability for all types of organoids was with 1,200 μg/mL vitamin C. From quantitative polymerase chain reaction analysis (qPCR analysis), MUC2 was upregulated for 129 ASF and C3H Conv when exposed to 600 μg/mL and 1,200 μg/mL vitamin C. It suggests that large amounts of glycoprotein may be produced after adding high concentrations of vitamin C. Since inflammatory bowel disease has low level of MUC2, this finding may be helpful in restoring mucosal health by upregulating the MUC2 gene while altering patient's microbiota (Sibila et al., Annals of the American Thoracic Society, 2016). These results are expected to have a positive translational impact because this bottom-up strategy would be instrumental in developing Vitamin C and B3 based orally available therapeutic strategies and formula for advancing the fields of gastrointestinal regenerative medicine.</AbstractText>
<CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Qi</LastName>
<ForeName>Yijun</ForeName>
<Initials>Y</Initials>
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</AffiliationInfo>
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<ForeName>Kaitlin M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Materials Science and Engineering, Iowa State University, Ames, Iowa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peroutka-Bigus</LastName>
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<Initials>N</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Bellaire</LastName>
<ForeName>Bryan</ForeName>
<Initials>B</Initials>
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<AffiliationInfo><Affiliation>Department of Vet Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wannemuehler</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Vet Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yoon</LastName>
<ForeName>Kyoung-Jin</ForeName>
<Initials>KJ</Initials>
<AffiliationInfo><Affiliation>Department of Vet Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Barrett</LastName>
<ForeName>Terrence A</ForeName>
<Initials>TA</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Division of Gastroenterology, University of Kentucky, Lexington, Kentucky.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Qun</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>348137</GrantID>
<Agency>PhRMA Foundation Research Starter Award</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>2RO1 DK095662</GrantID>
<Acronym>NH</Acronym>
<Agency>NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>1I01CX001353</GrantID>
<Agency>VA Merit</Agency>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Vitamin C and B3 as new biomaterials to alter intestinal stem cells.

Vitamin C and B3 as new biomaterials to alter intestinal stem cells.

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